Tag: atopic dermatitis therapy

ANTIPRURITIC EFFECT OF PRETREATMENT WITH TOPICAL CAPSAICIN 8% ON HISTAMINE- AND COWHAGE-EVOKED ITCH IN HEALTHY VOLUNTEERS

FCAAIA Notes: Itch is sometimes but not always from allergy. Histamine released from certain cells in the skin is one cause of itch.  In those cases, antihistamines might be useful symptoms relievers.  When itch is from allergy, topical or oral steroids might be helpful.

But what about itch from other causes?  For instance, molecules released from nerve endings (“neurotransmitters”) can also trigger “neurogenic” itch that will not respond to antihistamines or steroids.  In those cases, topical capsaicin might help. Capsaicin is the molecule in chili peppers that gives them their heat. When used on the skin Continue reading “ANTIPRURITIC EFFECT OF PRETREATMENT WITH TOPICAL CAPSAICIN 8% ON HISTAMINE- AND COWHAGE-EVOKED ITCH IN HEALTHY VOLUNTEERS”

NEW DRUGS FOR ATOPIC DERMATITIS BOOST TREATMENT OPTIONS

FCAAIA Notes: Atopic dermatitis (AD) is a common form of eczema. About90% of the time, its onset is before 5 years old.  It is characterized by (among other things) intense itch that can have a huge detrimental effect on quality of life. It is often described as a “rashy itch” more than an “itchy rash”. Itch leads to scratching that causes rashing.

One of the most important things that happens in AD is loss of water though the skin (“transepidermal water loss”, TEWL). So the main stay of treatment for AD is hydration of the skin with bathing and immediate application of moisturizers to trap the water in the skin (“soak and seal”). Topical corticosteroids help to decrease TEWL and oral antihistamines sometimes help control the itch.

These treatments are often not enough, especially when there is facial AD.  In those instances non-steroidal treatments can help. Continue reading “NEW DRUGS FOR ATOPIC DERMATITIS BOOST TREATMENT OPTIONS”

ECZEMA: DAILY “SOAK AND SMEAR” OR STEER CLEAR?

FCAAIA Notes: There are many types of “eczema” so the term is more a description, than a diagnosis.  Atopic dermatitis (AD) is the type of eczema studied in this paper.

AD is among other things a condition involving water loss from the skin (transepidermal water loss) resulting in dry skin.  It is also a condition that might be thought of as a “rashy itch” rather than an “itchy rash.”  That is, the itch precedes the rash. Continue reading “ECZEMA: DAILY “SOAK AND SMEAR” OR STEER CLEAR?”

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