FCAAIA Notes: It often takes a while before common variable immunodeficiency (CVID) is diagnosed after the onset of symptoms. Early on, its presentation can mimic asthma and allergic rhinitis with complications of recurrent infections. It can evolve insidiously, so seeing the same physician regularly might result in earlier diagnosis. But as also noted in this article, patients with allergic airway disease can develop CVID later.
Physicians need to be aware of CVID, know when to suspect it, and know how to make the diagnosis. Continue reading “IMMUNODEFICIENCY MAY BE COMPLICATED BY ASTHMA, ALLERGIES”
FCAAIA Notes: Patients with immune deficiency disease do get any more viral upper respiratory tract infections than anyone else. What they do get, is more frequent complications of those infections (ear and sinus infections and pneumonia). Most patients with recurrent ear, sinus, and lung infections do not have immune deficiency, but it is always a consideration. Those infections are often “over-treated” and are not bacterial at all or are complications of allergic rhinitis or asthma. So, other factors as described below need to be considered. Continue reading “IN RECURRENT UPPER RESPIRATORY INFECTIONS, DON’T ORDER THAT IMMUNE TEST JUST YET”
FCAAIA Notes: Common variable immunodeficiency (CVID) is a relatively rare disorder, but it is the most common primary immunodeficiency presenting in adults. It got its name because it can present with recurrent infections in a variety of ways with a variety of immunologic abnormalities. The cause is not known and in fact multiple molecular defects have been identified in CVID. It is probably not one disorder, but an array of disorders with similar presentations. Continue reading “THE AUTOIMMUNE CONUNDRUM IN COMMON VARIABLE IMMUNODEFICIENCY DISORDERS”